Sulfasalazine for rheumatoid arthritis
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Examples
| Brand Name | Chemical Name |
| Azulfidine | sulfasalazine |
Sulfasalazine is a medication formed from salicylic acid, the active ingredient in aspirin, and an antibiotic, sulfapyridine. It is given by mouth (orally) and is available in time-release tablets.
How It Works
Sulfasalazine reduces joint inflammation associated with rheumatoid arthritis and slows or stops the disease from getting worse. It is also often used to treat inflammatory bowel disease.
Why It Is Used
Sulfasalazine is used for early, milder cases of rheumatoid arthritis. It may be used with other medications, such as nonsteroidal anti-inflammatory drugs (NSAIDs), or with disease-modifying antirheumatic drugs (DMARDs) for more active rheumatoid arthritis.
People with sulfa or salicylate allergies should not use this medication.
How Well It Works
Studies indicate that sulfasalazine is effective in relieving the symptoms and slowing the progression of rheumatoid arthritis. Although sulfasalazine treatment may show results within 1 month, it typically takes several months to be effective.1
Side Effects
Sulfasalazine is usually well-tolerated. Side effects are usually temporary and may include:
- Skin rash.
- Nausea.
- Abdominal discomfort.
Rare side effects include low blood counts and allergic reactions.1
See Drug Reference for a full list of side effects. (Drug Reference is not available in all systems.)
What To Think About
Talk to your health professional before taking this medication if you are pregnant or thinking about becoming pregnant. Do not take sulfasalazine if you are breast-feeding.
Sulfasalazine has been used for many years to treat rheumatoid arthritis. It is usually used to treat people with early, milder cases of rheumatoid arthritis. It is used in combination with methotrexate and hydroxychloroquine in what is sometimes referred to as triple therapy. Research continues on sulfasalazine's effectiveness in halting the progression of rheumatoid arthritis in comparison with newer DMARDs, such as leflunomide (Arava), etanercept (Enbrel), and infliximab (Remicade).
Complete the new medication information form (PDF) (What is a PDF document?) to help you understand this medication.
References
Citations
Kwoh CK, et al. (2002). Guidelines for the management of rheumatoid arthritis. Arthritis and Rheumatism, 46(2): 328–346.
Credits
| Author | Robin Parks, MS |
| Editor | Kathleen M. Ariss, MS |
| Associate Editor | Pat Truman |
| Associate Editor | Terrina Vail |
| Primary Medical Reviewer | Kathleen Romito, MD - Family Medicine |
| Specialist Medical Reviewer | Stanford M. Shoor, MD - Rheumatology |
| Last Updated | August 23, 2006 |
Print This
| Last updated: | August 23, 2006 |
|---|---|
| Author: | Robin Parks, MS |
| Reviewed By: | Kathleen Romito, MD - Family Medicine, Stanford M. Shoor, MD - Rheumatology |
| Editors: | Kathleen M. Ariss, MS, Terrina Vail |
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